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Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is becoming popular may be the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise hypertension and heart rate, and really should not be used in those with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and pulse rate and must not used in patients with uncontrolled high hypertension, in addition to by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. 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Post-acute alcohol withdrawal symptoms (PAWS) may be managed promptly and effectively, which further improves comfort and reduces relapse rates; this contrasts sharply with inpatient facilities, where patients have already been discharged before post-acute withdrawal symptoms develop, leaving them non recourse with how to effectively and safely deal with them.